Comparison of two groups

Good afternoon, I would like to ask how to properly conduct an analysis for two groups. I have two groups: those who are good at math and those who are bad at math, help me calculate if there is a significant difference on each channel between the two groups, how to do it in MNE

Hello, if you want to compare the signal between groups, you should probably look into performing a cluster-based permutation test.

We cover that in some of our tutorials, although I have to say that I personally find these documents quite hard to follow. But they should give you a starting point.

I suggest you start working through:
https://mne.tools/stable/auto_tutorials/stats-sensor-space/10_background_stats.html

Good luck,
Richard