Can you do a spatio-temporal ANOVA cluster-based analysis on a Temporal Generalization data?

My question is if I can do Repeated measures ANOVA (2x2) on Temporal Generalization data using spatio-temporal clustering akin to here: Repeated measures ANOVA on source data with spatio-temporal clustering — MNE 1.11.0 documentation

and if yes what would be my adjacency matrix? Also what I am thinking of is it even statistically meaningful?