# Reliability of a source

**URL:** <https://mne.discourse.group/t/reliability-of-a-source/2062>\
**Category:** Mailing List Archive (read-only)\
**Tags:** list-archive\
**Created:** [February 4, 2020, 1:04pm UTC](https://mne.discourse.group/t/reliability-of-a-source/2062 "2020-02-04T13:04:24Z")\
**Posts on this page:** 5\
**Page:** 1

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**Author:** ![system](https://global.discourse-cdn.com/free1/uploads/mne/original/1X/85cc6bd2b69cb698a166dc6d880fb550510d0144.jpeg) [@system](https://mne.discourse.group/u/system)\
**Post date:** [February 4, 2020, 1:04pm UTC](https://mne.discourse.group/t/reliability-of-a-source/2062/1 "2020-02-04T13:04:24Z")

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Dear friends,  
I would like to proof reliability of a source reconstructed with dSPM. How  
to apply correction for multiple comparison (FDR or cluster-size) at the  
source level? How to setup a threshold for significant activation?  
Thank you very much for your help,  
Irina  
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**Author:** ![system](https://global.discourse-cdn.com/free1/uploads/mne/original/1X/85cc6bd2b69cb698a166dc6d880fb550510d0144.jpeg) [@system](https://mne.discourse.group/u/system)\
**Post date:** [February 8, 2020, 1:28pm UTC](https://mne.discourse.group/t/reliability-of-a-source/2062/2 "2020-02-08T13:28:31Z")

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hi Irina,

you should give us for details. What conditions / statistical test you  
have in mind?  
is it at the group level ?

you can find on the mne.tools website some examples eg using  
spatio-temporal cluster level stats.

HTH  
Alex

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**Author:** ![system](https://global.discourse-cdn.com/free1/uploads/mne/original/1X/85cc6bd2b69cb698a166dc6d880fb550510d0144.jpeg) [@system](https://mne.discourse.group/u/system)\
**Post date:** [February 9, 2020, 12:35pm UTC](https://mne.discourse.group/t/reliability-of-a-source/2062/3 "2020-02-09T12:35:22Z")

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Hi Alex,  
Thank you very much for your reply,  
I meant a group averaged evoked response (ERP/ERF) to auditory stimulation  
(when subjects are performing an active task). The individual dSPMs were  
morphed beforehand to a standard template. The group average shows strong  
activation within the auditory cortex, and weaker activation in another  
region of interest. The second region can be seen at a lower threshold,  
that can be adjusted using the interactive scale. So, I would like to find  
out whether this second activation is significant. Is there an objective  
way to set up the threshold for the significant activation (versus  
baseline)? Is it necessary to perform the FDR correction to the group  
averaged evoked responses (like we do for fMRI data)?  
Thank you very much for your help!  
Irina.

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**Author:** ![system](https://global.discourse-cdn.com/free1/uploads/mne/original/1X/85cc6bd2b69cb698a166dc6d880fb550510d0144.jpeg) [@system](https://mne.discourse.group/u/system)\
**Post date:** [February 13, 2020, 8:56pm UTC](https://mne.discourse.group/t/reliability-of-a-source/2062/4 "2020-02-13T20:56:58Z")

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Sorry for posting this question again...  
Thank you very much in advance!

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**Author:** ![system](https://global.discourse-cdn.com/free1/uploads/mne/original/1X/85cc6bd2b69cb698a166dc6d880fb550510d0144.jpeg) [@system](https://mne.discourse.group/u/system)\
**Post date:** [February 14, 2020, 9:54am UTC](https://mne.discourse.group/t/reliability-of-a-source/2062/5 "2020-02-14T09:54:50Z")

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Hi Irina,

I am sure other MNE users have suggestions on this but I can answer with  
what  
MNE-Python can offer at this stage which is to do: FDR correction on a  
paired t-test  
or spatio-temporal cluster level stats in source space.

Alex